FBI criminal profiler Will Graham (William L. Petersen) is called out of early retirement to assist on a serial murder case involving a killer known as the “Tooth Fairy” (Tom Noonan). Graham enlists the help of imprisoned serial killer — and cannibal — Dr. Hannibal Lecktor (Brian Cox), who is the reason Graham took early retirement. Soon, Graham and the FBI are entangled in a deadly cat-and-mouse game between the Tooth Fairy, Lecktor, and an interfering journalist (Stephen Lang).
A New York reporter heads to Australia to interview the living legend Mike Dundee (Paul Hogan). When she finally locates him, she is so taken with him that she brings him back with her to New York. In New York, Mike Dundee is amazed by the wonders of the city and the interesting people there.