FBI criminal profiler Will Graham (William L. Petersen) is called out of early retirement to assist on a serial murder case involving a killer known as the “Tooth Fairy” (Tom Noonan). Graham enlists the help of imprisoned serial killer — and cannibal — Dr. Hannibal Lecktor (Brian Cox), who is the reason Graham took early retirement. Soon, Graham and the FBI are entangled in a deadly cat-and-mouse game between the Tooth Fairy, Lecktor, and an interfering journalist (Stephen Lang).
In the 23rd century, a New York City cabbie, Korben Dallas (Bruce Willis), finds the fate of the world in his hands when Leeloo (Milla Jovovich) falls into his cab. As the embodiment of the fifth element, Leeloo needs to combine with the other four to keep the approaching Great Evil from destroying the world. Together with Father Vito Cornelius (Ian Holm) and zany broadcaster Ruby Rhod (Chris Tucker), Dallas must race against time and the wicked industrialist Zorg (Gary Oldman) to save humanity.