FBI criminal profiler Will Graham (William L. Petersen) is called out of early retirement to assist on a serial murder case involving a killer known as the “Tooth Fairy” (Tom Noonan). Graham enlists the help of imprisoned serial killer — and cannibal — Dr. Hannibal Lecktor (Brian Cox), who is the reason Graham took early retirement. Soon, Graham and the FBI are entangled in a deadly cat-and-mouse game between the Tooth Fairy, Lecktor, and an interfering journalist (Stephen Lang).
Billy Hoyle (Woody Harrelson) is a white basketball hustler who banks on black players underestimating his skills on the court. When he pulls one over on Sidney Deane (Wesley Snipes), his victim sees a lucrative opportunity, and they become partners in the con game, plying their trade across the courts of Los Angeles. Meanwhile, Billy has to keep one step ahead of mobsters, to whom he owes money, while staying on the good side of his “Jeopardy!”-obsessed, motormouth wife (Rosie Perez).