Sweethearts Brad and Janet stuck with a flat tire during a storm, discover the eerie mansion of Dr. Frank-N-Furter, a transvestite scientist. As their innocence is lost, Brad and Janet meet a houseful of wild characters, including a rocking biker and a creepy butler. Through elaborate dances and rock songs, Frank-N-Furter unveils his latest creation: a muscular man named ‘Rocky’.
FBI criminal profiler Will Graham (William L. Petersen) is called out of early retirement to assist on a serial murder case involving a killer known as the “Tooth Fairy” (Tom Noonan). Graham enlists the help of imprisoned serial killer — and cannibal — Dr. Hannibal Lecktor (Brian Cox), who is the reason Graham took early retirement. Soon, Graham and the FBI are entangled in a deadly cat-and-mouse game between the Tooth Fairy, Lecktor, and an interfering journalist (Stephen Lang).