Imbecilic best friends Lloyd Christmas (Jim Carrey) and Harry Dunne (Jeff Daniels) stumble across a suitcase full of money left behind in Harry’s car by Mary Swanson (Lauren Holly), who was on her way to the airport. The pair decide to go to Aspen, Colo., to return the money, unaware that it is connected to a kidnapping. As Harry and Lloyd who have fallen in love with Mary are pursued across the country by hired killers and police, they find both their friendship and their brains tested.
Lane Meyer (John Cusack) is a teen with a peculiar family and a bizarre fixation with his girlfriend, Beth (Amanda Wyss). When Beth dumps Lane, he decides to kill himself, making bumbling attempts at suicide. Outside of his morbid endeavors, Lane spends time with his oddball buddy, Charles (Curtis Armstrong), and befriends Monique (Diane Franklin), a visiting French student. Eventually, Lane resolves to race Beth’s obnoxious new beau on the ski slopes, with unexpected results.