New father Frank (Emilio Estevez) departs for a night out, joining friends Mike (Cuba Gooding Jr.) and Ray (Jeremy Piven) as they head to a boxing match. At the last minute, they are joined by John (Stephen Dorff), Frank’s brother. Stuck in gridlock traffic, the guys take a shortcut that gets them lost. In a very dangerous neighborhood, they witness a murder by a gang leader called Fallon (Denis Leary). They flee, but Fallon now wants them hunted down and and eliminated.
In a world where vampires walk the earth, Blade has a goal. His goal is to rid the world of all vampire evil. When Blade witnesses a vampire bite Dr. Karen Jenson, he fights away the beast and takes Jenson back to his hideout. Here, alongside Abraham Whistler, Blade attempts to help heal Jenson. The vampire Quinn who was attacked by Blade, reports back to his master Deacon Frost, who is planning a huge surprise for the human population.